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Academic Journal

Further Discussion on the Design and Analysis of Thorough QTc Clinical Trials: Guest Editors' Notes.

Authors : Tsong, Yi¹ (AUTHOR) ; Zhang, Joanne¹ (AUTHOR)

Subjects: LONG QT syndrome; CLINICAL trials

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p493-496. 4p.

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Academic Journal

The QT syndromes: long and short.

Authors : Morita, Hiroshi¹; Jiashin Wu¹; Zipes, Douglas P.¹

Subjects: LONG QT syndrome; ARRHYTHMIA; TACHYCARDIA diagnosis

Source: Lancet. 8/30/2008, Vol. 372 Issue 9640, p750-763. 14p.

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Revisit the Combination Validation Test of Tsong et al. for Thorough QT/QTc Clinical Trials.

Authors : Sun, Guowen (Gordon)¹ (AUTHOR) ; Quan, Hui¹ (AUTHOR)

Subjects: LETTERS to the editor; LONG QT syndrome

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p683-687. 5p. 1 Chart, 2 Graphs.

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Academic Journal

Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology.

Authors : Struijk, J. J.¹ ; Kanters, J. K.^2,3,4; Andersen, M. P.¹

Subjects: *DISCRIMINANT analysis; GENETIC disorders; ELECTROCARDIOGRAPHY

Source: Medical & Biological Engineering & Computing. Jul2006, Vol. 44 Issue 7, p543-549. 7p. 4 Charts, 4 Graphs.

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Academic Journal

Exposure-Response Modeling Approach for Assessing QT Effect in “Thorough” QT/QTc Studies.

Authors : Hosmane, Balakrishna¹ (AUTHOR) ; Locke, Charles² (AUTHOR); Chiu, Yi-Lin² (AUTHOR)

Subjects: *TESTING; LONG QT syndrome; THERAPEUTICS

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p615-640. 17p. 1 Chart, 2 Graphs.

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Academic Journal

A Comparison of Several Methods For Analyzing Data from Thorough QT Studies.

Authors : Tian, Hong¹ (AUTHOR) ; Qiao, Wenqian² (AUTHOR); Natarajan, Jaya¹ (AUTHOR)

Subjects: *DATA analysis; LONG QT syndrome; MEDICAL research

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p632-612. 9p. 2 Charts, 2 Graphs.

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Academic Journal

Response to Letter to the Editor: Statistical Issues of QT Prolongation Assessment Based on Linear Concentration Modeling by Yi Tsong et al.

Authors : Wang, Yaning¹ (AUTHOR) ; Garnett, Christine¹ (AUTHOR)

Subjects: LETTERS to the editor; LONG QT syndrome

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p689-692. 4p.

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Academic Journal

Statistical Consideration in Testing for Assay Sensitivity in a “Thorough” QT Study.

Authors : Sethuraman, Venkat¹ (AUTHOR) ; Wu, Shuang² (AUTHOR); Wang, Jixian¹ (AUTHOR)

Subjects: LONG QT syndrome; MYOCARDIAL depressants; ELECTROCARDIOGRAPHY

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p641-653. 13p. 1 Chart, 4 Graphs.

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Academic Journal

Multiple Comparisons of Repeatedly Measured Response: Issues of Validation Testing in Thorough QT/QTc Clinical Trials.

Authors : Tsong, Yi¹ (AUTHOR) ; Yan, LihanK.¹ (AUTHOR); Zhong, Jinglin¹ (AUTHOR)

Subjects: LONG QT syndrome; CLINICAL trials; PLACEBOS

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p654-664. 11p. 4 Charts.

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Academic Journal

Use of the Average Baseline Versus the Time-Matched Baseline in Parallel Group Thorough QT/QTc Studies.

Authors : Meng, Zhaoling¹ (AUTHOR) ; Quan, Hui¹ (AUTHOR); Fan, Li¹ (AUTHOR)

Subjects: *MULTIVARIATE analysis; *ANALYSIS of covariance; LONG QT syndrome

Source: Journal of Biopharmaceutical Statistics. May/Jun2010, Vol. 20 Issue 3, p665-682. 18p. 5 Charts, 4 Graphs.

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